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But in the wake of and the Trump administration’s decision to impose an energy blockade on Cuba — a key Mexican ally — Sheinbaum has taken a harder line.

“We’ve seen the president raise her tone,” said Palmira Tapia, an analyst for Mexico’s Center for Economic Research and Teaching. “There’s been a shift, and we’ve seen Sheinbaum be more vocal than before.”

Deaths in ICE custody

Sheinbaum's latest rebuke came on Tuesday, a day after 49-year-old Mexican citizen Alejandro Cabrera Clemente died in a detention center in Louisiana of the Immigration and Customs Enforcement agency, or ICE, the fifteenth death of a Mexican citizen in U.S. custody in little over a year.

Mexico's government quickly called the deaths “unacceptable” and the ICE detention centers "incompatible with human rights standards and the protection of life.”

During a Tuesday press briefing Sheinbaum added that she requested investigations into the deaths of the 15 migrants, and instructed Mexican consulates to visit detention centers daily.

She said her government would raise the deaths in detention centers to Inter-American Commission on Human Rights, and was considering appealing to the United Nations. Her government already said it would support lawsuits in the U.S. filed by detainees over poor conditions.

“We are going to defend Mexicans at every level,” Sheinbaum said, adding that “there are many Mexicans whose only crime is not having papers.”

The moves by Sheinbaum's government come on top of mounting disapproval in the U.S. of Trump's immigration enforcement. About 6 in 10 U.S. adults say Trump has “gone too far” in sending federal immigration agents into American cities, according to a February AP-NORC .

“Growing dissatisfaction around ICE activities in the United States creates a more comfortable platform for members of the Mexican government to raise concerns about the fate of Mexican citizens,” said Carin Zissis, vice president of content strategy for the Council of the Americas.

A ‘cool head’

Sheinbaum has maintained what she has described as a “cool head” to provocations by Trump, who has exerted more pressure on Latin America than any U.S. leader in decades. In just a few months, the Trump administration deposed Venezuela's president, and against Mexican cartels.

She has to balance maintaining a strong relationship with Trump while repeatedly stressing Mexico's sovereignty to appease her own base. Her measured responses resemble that of a lawyer rather than the head of Mexico’s most powerful populist political movement.

Her government has come down harder on cartels than her predecessor and bolstered trade relations ahead of renegotiations of the United States-Mexico-Canada Agreement, or USMCA, free trade agreement.

While Trump has taken public jabs at Sheinbaum — at one point suggesting cartels have greater control over Mexico than her government — he's also regularly made nods to their amicable relationship.

“She is really a nice person, I like her a lot,” he said last month, proceeding to imitate the Mexican leader in a high voice.

Divide over Cuba

But shifting geopolitics in the region, and the mounting deaths in ICE facilities, have also opened the door for Sheinbaum to take a firmer stance.

The main point of contention between the two governments has been Cuba. Solidarity with the U.S. adversary has been a cornerstone of Mexico’s political ethos since the Cuban revolution, which Fidel Castro, Ernesto “Che” Guevara and a group of exiles famously planned while in Mexico City. It's a particular sticking point with her progressive Morena party, whose founder ushered Sheinbaum into office.

The relationship hit a hurdle in late January, when Trump announced he would . The move directly impacted Mexico, which for years has shipped oil to Cuba.

While Sheinbaum reluctantly , she has continued to challenge the Trump administration's push for regime change.

“Mexico has every right to send fuel, whether for humanitarian or commercial reasons,” Sheinbaum said earlier this week.

She has described Trump's energy blockade of Cuba as “unjust” and accused the U.S. government of “suffocating” Cubans with sanctions. The Mexican leader has , and even donated $1,000 of her own money to relief efforts in a symbolic gesture.

“This is a Rubicon issue for her," said Arturo Sarukhan, former Mexican ambassador to the U.S.

Even then, the moves by the Mexican leader have raised eyebrows in Washington.

Sheinbaum recently announced that her country , diverging from other nations in Central America and the Caribbean that have ended their programs in the face of U.S. pressure.

It was met with veiled threats from the Trump administration, which pointed to visa restrictions imposed on Central American officials with ties to what U.S. Secretary of State Marco Rubio referred to as a “forced labor scheme.”

The White House offered no comment on Tuesday about Sheinbaum's tougher stances, nor did it comment on the rising number of deaths of Mexican nationals in ICE custody.

Greater leverage

Sheinbaum's recently bolder tone suggests a calculation that her administration can push back on some politically important fronts as long as they also are making progress on strengthening trade and meeting Trump administration requests on security and migration, Zissis said.

At the same time, surging energy prices due to the have made the U.S. more dependent on allies in Mexico, she and other analysts said, prompting Washington to walk back from any drastic moves against Mexican cartels or Cuba, at least in the short term.

”We’re at a moment where, due to global events, we’re facing different economic uncertainties. That gives the U.S. and Mexico more reason to work together," she said.

At the same time, former Mexican ambassador Sarukhan said that Sheinbaum will have to be careful not to put at risk upcoming USMCA renegotiations, for which her government has made painstaking efforts to build a strong foundation.

"What’s going to be interesting going forward is whether she can continue to have her cake and eat it too,” Sarukhan said.

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Weissert reported from Washington D.C.